Meaningless? I don't think so!
Antigliadin immunoglobulin A best in finding celiac disease in children younger than 18 months of age. 
PMID: 18852634   Oct 2008

Gliadin IgG antibodies and circulating immune complexes.
PMID: 18819035   2009

 

ANTIGLIADIN ANTIBODIES IN:

Crohn's Disease
High prevalence of celiac disease among patients affected by Crohn's disease. PMID: 15973121 July 2005

Diabetes

RESULTS: 17 [out of 34] patients had elevated IgG AGA, none showed elevated IgA AGA. Only one patient had elevated IgA and anti tTG levels, and a normal small intestinal biopsy. 28 patients had HLA DQ2 or DQ8 present.
Celiac disease in African American children with type 1 diabetes mellitus in inner city Brooklyn.
PMID: 18806716   Aug 2008

We found a significantly higher occurrence of gliadin antibodies in LADA patients: the rate of AGGAb was 19.1% in comparison with 3.5% in the T2DM group (P = 0.0026), the rate of AGAAb was 13.2% in comparison with 3.5% (P = 0.035). The prevalence of EMAb was very low in both groups (1.5% and 0).
Gliadin, endomysial and thyroid antibodies in patients with latent autoimmune diabetes of adults (LADA). PMID: 12823288 July 2003

[Risk markers for insulin-dependent diabetes mellitus and duration of exposure to gluten in celiac patients] PMID: 15478300 Aug 2004

Down Syndrome
Down syndrome and coeliac disease: usefulness of antigliadin and antiendomysium antibodies.
PMID: 9001668 Dec 1996

Prevalence of IgA-antigliadin antibodies and IgA-antiendomysium antibodies related to celiac disease in children with Down syndrome. PMID: 9445503 Feb 1998

IgA Deficiency
Role of human-tissue transglutaminase IgG and anti-gliadin IgG antibodies in the diagnosis of coeliac disease in patients with selective immunoglobulin A deficiency. PMID: 15571003 Nov 2004

Irritable Bowel Syndrome

The mechanism by which food activates mucosal immune system is uncertain, but food specific IgE and IgG4 appeared to mediate the hypersensitivity reaction in a subgroup of IBS patients. Exclusion diets based on skin prick test, RAST for IgE or IgG4, hypoallergic diet and clinical trials with oral disodium cromoglycate have been conducted, and some success has been reported in a subset of IBS patients.
Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review.
PMID: 16918724 Aug 2006


Determination of the level of specific markers of celiac disease (in our research--antigliadin Ig) is considered to be the optimal method of diagnostic celiac disease in this group of patients.
[Prevalence of undiagnosed celiac disease in patients with irritated bowel syndrome]  PMID: 14723137  Oct 2003

Liver Disease
Antigliadin antibody classes in chronic liver disease.
PMID: 1421449 Oct 1992

MS
Results - Highly significant increases compared with controls were found for IgA and IgG antibodies against gliadin and gluten. IgA antibodies against casein were significantly increased. Anti-endomycium and anti-transglutaminase antibodies were negative.
IgA antibodies against gliadin and gluten in multiple sclerosis. PMID: 15355487 Oct 2004

Psoriasis
Coeliac disease-associated antibodies correlate with psoriasis activity. PMID: 15491433 Oct 2004

[The significance of diet and associated factors in psoriasis.] PMID: 16758223 June 2006

Rheumatoid Arthritis
[Antigliadin antibodies in rheumatoid arthritis] PMID: 8293004 Mar 1993

Gliadin immune reactivity in patients with rheumatoid arthritis. PMID: 8575138 Sept 1995

Schizophrenia
Autoantibodies associated with psychiatric disorders. PMID: 16719797 May 2005
[could not find anything specific to antigliadin antibodies...but several newer studies looking at schizophrenia as an immune mediated disease]

The gluten connection: the association between schizophrenia and celiac disease. PMID: 16423158 Feb 2006

More schizophrenics than controls showed IgA antibody levels above the upper normal limit to gliadin, beta-lactoglobulin, and casein.
Specific IgA antibody increases in schizophrenia. PMID: 7772650 Mar 1995


SLE
The prevalence of antigliadin antibodies in patients with SLE has been reported to be 23%.14 None of these patients had an enteropathy on biopsy. The conclusion was that there is no association between CD and SLE, but an association between gluten sensitivity and SLE cannot be excluded. More likely, however, is the possibility of misdiagnosis of SLE in patients with gluten sensitivity.
Gluten sensitivity masquerading as systemic lupus erythematosus Feb 2004

Sjogren's
Even among nonceliac patients with primary Sjogren's syndrome, an ongoing inflammation is often present in the small bowel mucosa.
Celiac disease and markers of celiac disease latency in patients with primary Sjogren's syndrome. PMID: 10201480 April 1999

Thyroid disease
The presence of the antigliadin antibodies in autoimmune thyroid diseases. PMID: 15244201 Dec 2003

Ulcerative Colitis
High frequency of antigliadin antibodies and absence of antireticulin and antiendomysium antibodies in patients with ulcerative colitis. PMID: 10204612 Feb 1999

 
OTHER

Antigliadin antibodies (AGA) mark celiac disease, but AGA are also encountered in IgA-nephritis, psoriasis, sickle-cell anemia, hepatic disorders, juvenile rheumatoid arthritis, autoimmune thyroidism and in persons who occupationally contact great amounts of wheat. AGA IgA and/or IgG were registered in 19 of 60 subjects (51 adults and 9 children) with various immunomediated diseases without symptoms of celiac disease: in 4 cases of chronic active hepatitis, in 2 of 4 cases of chronic persistent hepatitis, in 4 of 16 cases of rheumatoid arthritis, in 3 of 19 cases of IgA-deficiency, in 1 of 8 cases of SLE, in 2 cases of postvaccine reaction, in all the single cases of juvenile rheumatoid arthritis, focal scleroderma, macroglobulinemia. IgA only occurred in in 6 patients, IgG- in 6 patients, both IgA and IgG in 7 patients. The most pronounced positive reaction to AGA was recorded in 8-year-old girl with juvenile rheumatoid arthritis. The emergence of AGA in immunomediated diseases may be attributed to the response to food protein in pathological conditions and is often unrelated closely with celiac disease.
[Antigliadin antibodies in the absence of celiac disease] PMID: 9553358 1998

Our results showed that while AGA-IgA were absent in all children studied, with the exception of 3 cases of acute diarrhoea, a moderate percentage of AGA-IgG was observed in subjects with cow's milk protein intolerance, acute diarrhoea, irritable bowel syndrome, lactase deficiency, chronic intractable diarrhoea and in a low percentage of children with parasitosis, intestinal lymphangiectasia and nodular lymphoid hyperplasia.
The predictive value of antigliadin antibodies (AGA) in the diagnosis of non-celiac gastrointestinal disease in children] PMID: 8341233 Mar 1993

CONCLUSIONS: IgA-class antireticulin or antigliadin antibody-positive patients with normal small-bowel mucosal morphology frequently have immunohistochemical markers of coeliac disease latency. Together with our follow-up data this implies that they may be gluten-sensitive.
Small-bowel mucosal inflammation in reticulin or gliadin antibody-positive patients without villous atrophy. PMID: 9759950 Sept 1998

We describe a unique case of atypical natural killer (NK)-cell proliferation likely related to gluten sensitivity, mimicking NK-cell lymphoma. >>> Two years after initial presentation, the patient was found to have high titers of antigliadin antibodies with no other evidence of celiac disease. After instituting a gluten-free diet, many of the lesions regressed, suggesting that this atypical NK-cell proliferation may be driven by an anomalous immune response. Awareness of this case may prevent pathologists from misdiagnosing similar lesions as NK/T-cell lymphomas. It is as yet unknown whether this process occurs more commonly in patients with gluten sensitivity, or in other settings, and the pathogenesis is as yet undetermined.
Atypical NK-cell proliferation of the gastrointestinal tract in a patient with antigliadin antibodies but not celiac disease.
PMID: 16625103 April 2006

CONCLUSION: We show that Caucasian Argentine women with RPL showed significantly higher incidence of anticardiolipin antibodies than normal controls and finally we recommended the screening of IgA and IgG antigliadina and IgA antitransglutaminase antibodies in pregnancy, because of the high prevalence of subclinical CD in RPL and the chance of reversibility through consumption of a gluten free diet.
Autoantibodies in Argentine women with recurrent pregnancy loss. PMID: 16451354  March 2006

Longitudinal follow-up examination of antigliadin antibody positive children and adults. PMID: 16607144 May 2006

Antigliadin antibodies associated with chronic mucocutaneous candidiasis. PMID: 12383098 Sept 2002